Impaired sensitivity to thyroid hormones is associated with increased body fat mass/muscle mass ratio (F/M) in the euthyroid population.

ABSTRACT:

Objective

To explore the relationship between body fat mass/muscle mass ratio (F/M) and thyroid hormone sensitivity in the euthyroid population.

Methods

Body compositions of 845 check-up individuals were determined using bioelectrical impedance analysis (BIA). Biochemical indexes including blood glucose, blood lipids, liver and kidney functions and thyrotropic hormones (THs) were detected. Free triiodothyronine to free thyroxine ratio (FT3/FT4), Thyroid Feedback Quantile-based Index (TFQI), Thyrotropin Thyroxine Resistance Index (TT4RI) and TSH Index (TSHI) were calculated for analysis.

Results

TT4RI and TSHI showed increased trends with statistical difference, while FT3/FT4 and TFQI showed no difference among F/M quartile groups. After adjusting for confounding facto

SUBMITTER: Li Y 

PROVIDER: S-EPMC12001440 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature