Antimicrobial, antibiofilm, cytotoxicity, and anti-DNA topoisomerase activity of Streptomyces sp. 22SH with ADME and in silico study.

ABSTRACT: The genus Streptomyces has been recently proven to be a valuable and rich source of producing several bioactive compounds with substantial biological activity and applications in many fields such as medicine, environmental science, food industries, and agronomy. This study highlights the importance of Streptomyces as an antimicrobial, antibiofilm, and anticancer. Out of the 75 actinobacteria isolated from both marine and soil habitats, one isolate, HG2, was selected based on its potent antimicrobial activity. The isolate has been identified morphologically by studying colony and spore chain morphology using TEM and genetically by sequencing their 16 sr RNA gene as Streptomyces sp. 22SH with Accession number OK326829.1. Bioassay-guided fractionation of the Streptomyces sp. 22SH crude extrac

SUBMITTER: Hassan MG 

PROVIDER: S-EPMC12001559 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature