Genomic structural equation modeling elucidates the shared genetic architecture of allergic disorders.

ABSTRACT:

Background

The intricate shared genetic architecture underlying allergic disorders-including allergic asthma, atopic dermatitis, contact dermatitis, allergic rhinitis, allergic conjunctivitis, allergic urticaria, anaphylaxis, and eosinophilic esophagitis-remains incompletely characterized.

Methods

Our study employed genomic structural equation modeling (Genomic SEM) to define the common factor representing the shared genetic architecture of allergic disorders. Coupled with diverse post-GWAS analytical methods, we aimed to discover susceptible loci and investigate genetic associations with external traits. Furthermore, we explored enriched genetic pathways, cellular layers, and genomic elements, and investigated putative plasma protein biomarkers. Polygenic risk score (PRS) a

SUBMITTER: Ruan J 

PROVIDER: S-EPMC12001568 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature