Optimizing Cost-Effective gene expression phenotyping approaches in cattle using 3' mRNA sequencing.

ABSTRACT:

Background

Genetic and genomic selection programs require large numbers of phenotypes observed for animals in shared environments. Direct measurements of phenotypes like meat quality, methane emission, and disease susceptibility are difficult and expensive to measure at scale but are critically important to livestock production. Our work leans on our understanding of the "Central Dogma" of molecular genetics to leverage molecular intermediates as cheaply-measured proxies of organism-level phenotypes. The rapidly declining cost of next-generation sequencing presents opportunities for population-level molecular phenotyping. While the cost of whole transcriptome sequencing has declined recently, its required sequencing depth still makes it an expensive choice for wide-scale molecular

SUBMITTER: Mohamed RI 

PROVIDER: S-EPMC12001630 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature