Central and peripheral adiposity and premenopausal breast cancer risk: a pooled analysis of 440,179 women.

ABSTRACT:

Background

Among premenopausal women, higher body mass index (BMI) is associated with lower breast cancer risk, although the underlying mechanisms are unclear. Investigating adiposity distribution may help clarify impacts on breast cancer risk. This study was initiated to investigate associations of central and peripheral adiposity with premenopausal breast cancer risk overall and by other risk factors and breast cancer characteristics.

Methods

We used individual-level data from 14 prospective cohort studies to estimate hazard ratios (HRs) for premenopausal breast cancer using Cox proportional hazards regression. Analyses included 440,179 women followed for a median of 7.5 years (interquartile range: 4.0-11.3) between 1976 and 2017, with 6,779 incident premenopausal breast c

SUBMITTER: Schoemaker MJ 

PROVIDER: S-EPMC12001638 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature