Plasma proteomic biomarkers of physical frailty in heart failure: a propensity score matched discovery-based pilot study.

ABSTRACT:

Background

Physical frailty is highly prevalent in heart failure (HF), but we lack an understanding of the underlying pathophysiology. Proteomic evaluation of plasma samples may elucidate potential mechanisms and biomarkers of physical frailty in HF.

Objectives

We aimed to identify plasma proteomic biomarkers that are differentially expressed between physically frail and non-physically frail adults with HF.

Methods

This was a secondary analysis of a subset of data and plasma samples from a study of frailty among patients with New York Heart Association (NYHA) Functional Classification I-IV HF. Physical frailty was measured using the Frailty Phenotype Criteria. Propensity score matching was used to match pairs of physically frail (n = 20) vs. non-physically frail (n = 

SUBMITTER: Denfeld QE 

PROVIDER: S-EPMC12001641 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature