A two-centre study investigating the association between brain natriuretic peptides & outcomes in continuous flow left ventricular assist device recipients.

ABSTRACT:

Background

Natriuretic peptides are useful prognostic markers in patients with heart failure and this study aims to evaluate the association between N-terminal pro-brain natriuretic peptide and outcomes in patients with a continuous-flow left ventricular assist device.

Methods

Adult patients with a continuous-flow left ventricular assist device as bridge to transplant or destination therapy and discharged from hospital were included in the study. Multi-variable Cox regression models with natriuretic peptide as a time-dependent covariate modelling multiple measures per patient, and cubic spline analysis were used to evaluate the association between natriuretic peptides and patient outcomes, taking median N-terminal pro-brain natriuretic peptide of 244 pmol/L as the reference

SUBMITTER: Lambadaris M 

PROVIDER: S-EPMC12001697 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature