PelD is required downstream of c-di-GMP for host specialization of Pseudomonas lurida.

ABSTRACT:

Background

The bacterial second messenger c-di-GMP is known to influence the formation of biofilms and thereby persistence of pathogenic and beneficial bacteria in hosts. A previous evolution experiment with Pseudomonas lurida MYb11, occasional symbiont of the nematode Caenorhabditis elegans, led to the emergence of host-specialized variants with elevated intracellular c-di-GMP. Thus far, the molecular underpinnings of c-di-GMP-mediated host specialization were unknown in this symbiosis. Therefore, the current study aimed at identifying candidate molecular processes by combining transcriptomic and functional genetic analyses.

Results

We found that MYb11 host specialists differentially expressed genes related to attachment, motility and biofilm production, including pelD from

SUBMITTER: Czerwinski A 

PROVIDER: S-EPMC12001729 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature