Fecal profiling reveals a common microbial signature for pancreatic cancer in Finnish and Iranian cohorts.

ABSTRACT:

Background

Pancreatic cancer (PC) presents a significant challenge in oncology because of its late-stage diagnosis and limited treatment options. The inadequacy of current screening methods has prompted investigations into stool-based assays and microbial classifiers as potential early detection markers. The gut microbiota composition of PC patients may be influenced by population differences, thereby impacting the accuracy of disease prediction. However, comprehensive profiling of the PC gut microbiota and analysis of these cofactors remain limited. Therefore, we analyzed the stool microbiota of 33 Finnish and 50 Iranian PC patients along with 35 Finnish and 34 Iranian healthy controls using 16S rRNA gene sequencing. We assessed similarities and differences of PC gut microbiota in

SUBMITTER: Sammallahti H 

PROVIDER: S-EPMC12001732 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature