Regulatory B-Cells Are Associated Negatively With Regulatory T-Cells and Positively With Cytokines in Peripheral Blood of Pregnant Women.

ABSTRACT:

Problem

Regulatory B-cells (Bregs, CD19⁺CD24^hiCD38^hi) are a specialized B-cell subset that suppresses immune responses and potentially contribute to the maintenance of an immune-privileged environment for fetal development during pregnancy. However, little is known about the surrounding immunological environment of Bregs in gestational physiology. The relationship of regulatory T-cells (Tregs, CD4⁺CD25^hiCD127^loFoxP3⁺) to Bregs in coordinating immunoregulation during pregnancy is unknown. We aimed to determine whether peripheral concentrations of Bregs and/or PD-L1-expressing Bregs correlated with Tregs and cytokines during pregnancy.

Method

Peripheral blood samples were obtained from 29 pregnant wom

SUBMITTER: Wiley KS 

PROVIDER: S-EPMC12001748 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature