Transmissible <i>Staphylococcus pseudintermedius</i> thwarts neutrophil extracellular trap-driven containment to promote invasive disease.

ABSTRACT: Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is an emerging zoonotic pathogen that causes a variety of clinical diseases in mammalian hosts. While it frequently causes infections in dogs and other domestic animals, accumulating evidence indicates that zoonotic spillover and cross-species transmission events favour local and invasive S. pseudintermedius infections in humans. However, immuno-evasive maneuvers that shape S. pseudintermedius pathogenicity and survival in diseased hosts remain enigmatic. Powered by multi-tech imaging and a mouse model of bloodstream infection, we illustrate that S. pseudintermedius adopted a virulence mechanism from predominant bacterial pathogens to surmount neutrophilic responses and neutrophil extracellular trap (N

SUBMITTER: Haller R 

PROVIDER: S-EPMC12001851 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature