A pilot study of a ketogenic diet in bipolar disorder: clinical, metabolic and magnetic resonance spectroscopy findings.

ABSTRACT:

Background

Preliminary evidence suggests that a ketogenic diet may be effective for bipolar disorder.

Aims

To assess the impact of a ketogenic diet in bipolar disorder on clinical, metabolic and magnetic resonance spectroscopy outcomes.

Method

Euthymic individuals with bipolar disorder (N = 27) were recruited to a 6- to 8-week single-arm open pilot study of a modified ketogenic diet. Clinical, metabolic and MRS measures were assessed before and after the intervention.

Results

Of 27 recruited participants, 26 began and 20 completed the ketogenic diet. For participants completing the intervention, mean body weight fell by 4.2 kg (P < 0.001), mean body mass index fell by 1.5 kg/m² (P < 0.001) and mean systolic blood pressure fell by

SUBMITTER: Campbell IH 

PROVIDER: S-EPMC12001942 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature