Beyond Phenolics: Alternative Substrates for Type III Copper Enzymes.

ABSTRACT: The type III copper enzyme family of tyrosinases (TYRs) catalyzes the ortho-hydroxylation and oxidation of phenols as well as the two-electron oxidation of catechols to ortho-quinones. TYRs use copper ions as their tightly bound cofactors and utilize molecular oxygen as their cosubstrate. They are responsible for physiologically important reactions like the formation of melanin, the primary pigment animals apply for protection against UV light. While the reactivity of TYRs on substrates containing aromatic hydroxy groups (i. e. phenols) is well recognized, reports clearly demonstrating that TYRs are active on aromatic amines as well have gone largely unnoticed. In this perspective we aim to bring together the sparse data on non-phenolic TYR substrates to illustrate the potential of TYRs fo

SUBMITTER: Pretzler M 

PROVIDER: S-EPMC12002105 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature