MicroRNA-218-5p coordinates scaling of excitatory and inhibitory synapses during homeostatic synaptic plasticity.

ABSTRACT: Homeostatic synaptic plasticity (HSP) is a neuronal mechanism that allows networks to compensate for prolonged changes in activity by adjusting synaptic strength. This process is crucial for maintaining stable brain function and has been implicated in memory consolidation during sleep. While scaling of both excitatory and inhibitory synapses plays an important role during homeostatic synaptic plasticity, molecules coordinating these processes are unknown. In this study, we investigate the role of miR-218-5p as a regulator of inhibitory and excitatory synapses in the context of picrotoxin (PTX)-induced homeostatic synaptic downscaling (HSD) in rat hippocampal neurons. Using enrichment analysis of microRNA-binding sites in genes changing upon PTX-induced HSD, we bioinformatically predict and

SUBMITTER: Colameo D 

PROVIDER: S-EPMC12002172 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature