Manipulation of interoceptive signaling biases decision making in rhesus macaques.

ABSTRACT: Several influential theories have proposed that interoceptive signals, sent from the body to the brain, contribute to neural processes that coordinate complex behaviors. We altered the physiological state of the body using compounds that have minimal effect on the brain and evaluated their effect on decision making in rhesus monkeys. We used glycopyrrolate, a nonspecific muscarinic (parasympathetic) antagonist, and isoproterenol, a beta-1/2 (sympathetic) agonist, to create a sympathetic-dominated state in the periphery, that was indexed by increased heart rate. Rhesus monkeys were trained on two variants of an approach-avoidance conflict task. The tasks offered a choice between enduring mildly aversive stimuli in exchange for a steady flow of rewards, or canceling the aversive stimuli, for

SUBMITTER: Cardenas MA 

PROVIDER: S-EPMC12002244 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature