Dopaminergic neurons in the paraventricular hypothalamus extend the food consumption phase.

ABSTRACT: Feeding behavior is controlled by various neural networks in the brain that are involved in different feeding phases: Food procurement, consumption, and termination. However, the specific neural circuits controlling the food consumption phase remain poorly understood. Here, we investigated the roles of dopaminergic neurons in the paraventricular nucleus of the hypothalamus (PVH) in the feeding behavior in mice. Our results indicated that the PVH dopaminergic neurons were critical for extending the food consumption phase and involved in the development of obesity through epigenetic mechanisms. These neurons synchronized with proopiomelanocortin neurons during consumption, were stimulated by proopiomelanocortin activation, and projected to the lateral habenula (LHb), where dopamine receptor

SUBMITTER: Ariyani W 

PROVIDER: S-EPMC12002271 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature