Discovery and functional characterization of a bombesin-type neuropeptide signaling system in an invertebrate.

ABSTRACT: Neuropeptide signaling systems are key regulators of physiological and behavioral processes in animals. However, the evolutionary history of some neuropeptides originally discovered in vertebrates is unknown. The peptide bombesin (BN) was first isolated from the skin of the toad Bombina bombina and subsequently BN-related neuropeptides have been identified in other chordates, including gastrin-releasing peptide (GRP) and neuromedin B (NMB) in mammals, and a GRP-like peptide in the cephalochordate Branchiostoma japonicum. However, BN-type neuropeptides have hitherto not been identified in any nonchordate animals. Here, we report the discovery and functional characterization of a BN-type neuropeptide signaling system in an echinoderm-the starfish Asterias rubens. BN-type

SUBMITTER: Huang W 

PROVIDER: S-EPMC12002301 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature