Optogenetic stimulation of the dorsal striatum bidirectionally controls seizures.

ABSTRACT: Despite a century of development of antiseizure medications, up to a third of people with epilepsy do not achieve seizure freedom with drug therapy. Deep brain stimulation is of growing use, but just as with pharmacotherapy, is not universally effective. Identifying new targets for deep brain stimulation-and in particular sites that are effective against a range of seizure types-may close this gap. Engagement of the basal ganglia experimental seizures was first observed almost 75 y ago. However, the role of the basal ganglia's input nucleus, the striatum, in seizure control is relatively understudied. To address this gap, we used an optogenetic approach to activate and inactivate neurons in the dorsal striatum of rats submitted to the gamma-butyrolactone (GBL) model of absence epilepsy, am

SUBMITTER: Hyder SK 

PROVIDER: S-EPMC12002315 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature