Evaluation and Characterization of Acute respiratory distress syndrome in tree shrews through TMT proteomic method.

ABSTRACT: Acute respiratory distress syndrome (ARDS), a common cause of acute fatal respiratory, is characterized by severe inflammatory lung injury as well as hallmarks of increased pulmonary vascular permeability, neutrophil infiltration, and macrophage accumulation. Tree shrew, a squirrel-like small animal model, has been confirmed to have more similar traits to human ARDS with one-hit intratracheal instillation of LPS in our previous study. In this study, we characterized protein profile changes induced by intranasal LPS challenge in the tree shrew model through tandem mass tag (TMT)-based quantitative proteomics and type II alveolar epithelial cells through pathological analysis. In total, 4070 proteins (p <  0.05) were identified from lung tissues of the LPS-induced group and PBS group. Among

SUBMITTER: Xiong J 

PROVIDER: S-EPMC12002456 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature