Ferroptosis regulation by traditional chinese medicine for ischemic stroke intervention based on network pharmacology and data mining.

ABSTRACT:

Objective

The aim of this study is to use network pharmacology and data mining to explore the role of traditional Chinese medicine (TCM) in ischemic stroke (IS) intervention by ferroptosis regulation. The results will provide reference for related research on ferroptosis in IS.

Methods

The ferroptosis-related targets were obtained from the GeneCards, GeneCLiP3, and FerrDdb databases, while the IS targets were sourced from the GeneCards and DisGeNET databases. Venny was used to identify IS targets associated with ferroptosis. A protein-protein interaction (PPI) analysis was then conducted, and machine learning screening was used to validate these potential targets. The potential targets that met specific criteria and their related compounds allowed us to select TCMs. A mechan

SUBMITTER: Lei J 

PROVIDER: S-EPMC12002469 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature