Sensitivity of multi-parametric quantitative magnetic resonance imaging for multiple sclerosis pathology.

ABSTRACT:

Background

In recent years, quantitative magnetic resonance imaging (MRI) made progress towards clinical applicability mainly through advances in acceleration techniques. In patients with multiple sclerosis (MS), objective quantitative MRI-based characterization of subtle pathological alterations in lesions, perilesion (PL), as well as normal-appearing (NA) white matter (NAWM) and grey matter (NAGM) would revolutionize clinical assessment. While numerous quantitative techniques have been applied in studies of MS patients, their diagnostic significance especially for individual patients with relatively short disease duration is unclear. Therefore, we investigated the sensitivity of several quantitative MRI parameters to focal and diffuse MS pathology in a clinical feasibility study

SUBMITTER: Schlaeger S 

PROVIDER: S-EPMC12002544 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature