Insights into optimization of oleaginous fungi - genome-scale metabolic reconstruction and analysis of <i>Umbelopsis</i> sp. WA50703.

ABSTRACT: Oleaginous fungi-known for their high lipid content of up to 80 % of dry mass-are of significant interest for biotechnological applications, particularly in biofuel and fatty acid production. Among these, the genus Umbelopsis, a common soil saprotroph of the Mucoromycota phylum, stands out for its rapid growth, low nutritional requirements, and ability to produce substantial amounts of lipids, especially polyunsaturated fatty acids (PUFAs). Despite previous studies on lipid production in Umbelopsis, metabolic engineering has been underexplored. This study fills that gap by presenting the first comprehensive metabolic model for Umbelopsis sp. WA50703, encompassing 2418 metabolites, 2215 reactions, and 1627 genes (iUmbe1). The model demonstrated a strong predictive accur

SUBMITTER: Dziurzynski M 

PROVIDER: S-EPMC12002602 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature