Amyloidogenesis promotes HSF1 activity enhancing cell survival during breast cancer metastatic colonization.

ABSTRACT: Breast cancer is the most commonly diagnosed cancer among women and the second leading cause of cancer deaths in women. A majority of these breast cancer deaths are due to metastasis, which occurs when primary tumor cells invade into the blood stream to travel and colonize at distant organ sites. Metastatic colonization is the rate-limiting step of metastasis. Heat shock factor 1 (HSF1) is a transcription factor that has been shown to be involved in promoting malignancy with a function in metastatic dissemination due to its contribution to promoting epithelial-to-mesenchymal transition. The role of HSF1 in colonization is unclear. In this study, we observed that HSF1 was essential for metastatic colonization. Consistent with these findings, we also observed that HSF1 was more active in hum

SUBMITTER: Hockaden N 

PROVIDER: S-EPMC12002613 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature