In-feed oxolinic acid induces oxidative stress and histopathological alterations in Nile tilapia <i>Oreochromis niloticus</i>.

ABSTRACT: The aquaculture industry urgently requires effective bacterial disease management strategies, necessitating better regulation of antibiotic application. This study investigated the effects of oral oxolinic acid (OA) administration on Oreochromis niloticus at the recommended dose of 12 mg (1 ×) and overdose of 36 mg (3 ×)/kg biomass/day for 7 consecutive days in terms of growth, oxidative stress, residue accretion and histopathology relative to the control. The 1 × and 3 × groups experienced dose-dependent mortalities (3.33-8.33 %). The OA residues peaked in the liver and kidney tissues with dosing and declined upon discontinuation. The residues persisted in the kidney even on day 35 post-dosing. Elevated malondialdehyde and total nitric oxide levels signified oxidative stress and co

SUBMITTER: Abraham TJ 

PROVIDER: S-EPMC12002751 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature