Butyric acid from ligilactobacillus animalis 2020MB acts on membrane BamA to control avian pathogenic escherichia coli.

ABSTRACT: Avian pathogenic Escherichia coli can cause high morbidity, mortality, and serious economic losses to the global poultry industry. Lactic acid bacteria inhibit the growth of many pathogens, including E. coli, but the underlying mechanism remains unclear. In this study, we investigated the effect of the cell-free supernatant of Ligilactobacillus animalis 2020MB isolated from the intestinal tract of chickens on specific pathogen-free chickens infected with E. coli. The cell-free supernatant-induced inhibition of E. coli infection was determined through clinical symptom observation, pathological analysis, and qPCR. Protease and heat treatments did not affect the antibacterial activity of cell-free supernatant, suggesting that an organic acid was the antibacterial substance. Liquid chromatogra

SUBMITTER: Yin H 

PROVIDER: S-EPMC12002762 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature