HISSTA: a human in situ single-cell transcriptome atlas.

ABSTRACT:

Motivation

Spatial transcriptomics holds great promise for revolutionizing biology and medicine by providing gene expression profiles with spatial information. Until recently, spatial resolution has been limited, but advances in high-throughput in situ imaging technologies now offer new opportunities by covering thousands of genes at a single-cell or even subcellular resolution, necessitating databases dedicated to comprehensive coverage and analysis with user-friendly intefaces.

Results

We introduce the HISSTA database, which facilitates the archival and analysis of in situ transcriptome data at single-cell resolution from various human tissues. We have collected and annotated spatial transcriptome data generated by MERFISH, CosMx SMI, and Xenium techniques, encompassing 11

SUBMITTER: Yu J 

PROVIDER: S-EPMC12002909 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature