Spleen proteome profile reveals immune responses induced by dietary spray-dried plasma against Salmonella Enteritidis infection in broiler chicks.

ABSTRACT: Salmonella infection severely impacts poultry health, productivity, and food safety. Spray dried plasma (SDP) shows good efficacy as an alternative to in-feed antibiotics for broiler chickens. Our objective was to identify potential mechanisms of SDP benefits by analyzing effects on spleen proteome and in response to Salmonella Enteritidis challenge (SE). A 2 × 2 factor study of broilers (n = 240) were assigned to CON (control) or SDP (30g/kg) diet at 1 day of age, and gavaged with sterile tryptic soy or 7.46 × 10⁸ CFU SE /mL, resulting in 4 groups CON (n = 60), SDP (n = 60), CON-SE (n = 60) and SDP-SE (n = 60). On d 2 and d 5 post-challenge, chicks (n = 4/treatment) were euthanized, and spleen collected to isolate proteins, and measure using label-free liquid chromatography tan

SUBMITTER: Ogundare TE 

PROVIDER: S-EPMC12002916 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature