TGFβ links EBV to multisystem inflammatory syndrome in children.

ABSTRACT: In a subset of children and adolescents, SARS-CoV-2 infection induces a severe acute hyperinflammatory shock¹ termed multisystem inflammatory syndrome in children (MIS-C) at four to eight weeks after infection. MIS-C is characterized by a specific T cell expansion² and systemic hyperinflammation³. The pathogenesis of MIS-C remains largely unknown. Here we show that acute MIS-C is characterized by impaired reactivation of virus-reactive memory T cells, which depends on increased serum levels of the cytokine TGFβ resembling those that occur during severe COVID-19 (refs. ^4,5). This functional impairment in T cell reactivity is accompanied by the presence of TGFβ-response signatures in T cells, B cells and monocytes along with reduced antigen-present

SUBMITTER: Goetzke CC 

PROVIDER: S-EPMC12003184 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature