The critical threshold of blood flow associated with spinal cord ischemia in a modified rabbit model developed by ligation of lumbar arteries.

ABSTRACT:

Study design

Animal study.

Objectives

To investigate the influence of lumbar arteries ligation on spinal cord blood flow (SCBF), and to determine by what proportion the SCBF decrease would cause spinal cord ischemia (SCI) in rabbit model.

Setting

Sir Run Run Shaw Hospital, Zhejiang University School of Medicine.

Methods

SCI model was established by ligation of lumbar arteries in rabbits. 20 rabbits were divided into four groups: group A, sham surgery without ligation; group B, ligation at 3 levels; group C, ligation at 4 levels; group D, ligation at 5 levels. The SCBF was measured with laser doppler flowmetry, motor function was assessed using modified Tarlov grading system, and neurophysiological integrity was detected with motor-evoked potential (MEP), follow

SUBMITTER: Xing LF 

PROVIDER: S-EPMC12003188 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature