MiR-126-5p suppresses HeLa and Ishikawa cell proliferation and migration via the RICTOR/AKT pathway.

ABSTRACT:

Objectives

Uterine cancer is a leading gynecological malignancy with increasing incidence and mortality rates, particularly in regions such as the United States and China. Despite advancements in treatment, current therapeutic strategies are often limited by tumor heterogeneity, therapy resistance, and a lack of targeted treatment options. These challenges underscore the urgent need for novel therapeutic approaches to improve patient outcomes. This study aims to investigate the role of miR-126-5p in uterine cancer pathogenesis, focusing on its potential as a therapeutic target to address these limitations.

Method

The study employed HeLa (cervical cancer) and Ishikawa (endometrial adenocarcinoma) cell lines to evaluate the effects of miR-126-5p on cell proliferation, migratio

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12003226 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature