Emergence and characterization of IncFII/IncR plasmids with multiple 5,692 bp- <i>bla</i> _KPC-2-bearing tandem repeats in ceftazidime/avibactam non-susceptible <i>Klebsiella pneumoniae</i> strains.

ABSTRACT: Ceftazidime/avibactam (CAZ/AVI) is widely recognized as an effective treatment for infections caused by KPC-producing Klebsiella pneumoniae (KPC-Kp). However, the prevalence of CAZ/AVI resistance among KPC-Kp isolates has increased rapidly in recent years. In this study, high-level carbapenem resistance and enhanced CAZ/AVI resistance were observed in two hypervirulent carbapenem-resistant K. pneumoniae isolates, KP1878 and KP3034, following prolonged carbapenem use. Virulence phenotypes were confirmed using the string test and a Galleria mellonella larvae infection model. Real-time quantitative PCR revealed that the relative expression of bla _KPC-2 in KP1878 and KP3034 was 2.4-fold and 11.6-fold higher, respectively, than that in the CAZ/AVI-suscepti

SUBMITTER: Liu H 

PROVIDER: S-EPMC12003348 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature