Increased risk of skin cancers in mucous membrane pemphigoid: a large-scale matched cohort study of 117 million US individuals.

ABSTRACT:

Introduction

Mucous membrane pemphigoid (MMP) is an autoimmune disease affecting the oral mucosa, conjunctivae and other mucous membranes. The mainstay treatment options are local and systemic corticosteroids and immunomodulatory therapies. Current research on cancer risk in MMP is scarce and has yielded conflicting results.

Methods

The aim of this study was to investigate the risk of developing skin cancer in patients with MMP by performing a large-scale, retrospective matched cohort study utilizing data from over 117 million US individuals. The risk of skin cancer in patients with MMP was observed within a 5-year follow-up period, along with three temporal difference analyses and stratification for disease severity.

Results

MMP was associated with an increased risk

SUBMITTER: Nouri A 

PROVIDER: S-EPMC12003376 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature