Spring viraemia of carp virus modulates the time-dependent unfolded protein response to facilitate viral replication.

ABSTRACT:

Introduction

The spring viraemia of carp virus (SVCV) poses a significant threat to global aquaculture, yet effective antiviral drugs and vaccines remain unavailable. Understanding the interplay between host-pathogen interactions and SVCV replication is crucial for devising preventive strategies.

Methods

ZF4 cells were exposed to UV-inactivated SVCV or live SVCV at different multiplicities of infection, and the modulation of the unfolded protein response (UPR) was assayed by qPCR at different times. Moreover, ZF4 cells were treated with several UPR modulators to investigate their effect on viral replication. The UPR was also modulated in vivo in zebrafish larvae, and its impact on the survival against SVCV infection was evaluated.

Results and conclusions

This s

SUBMITTER: Romero A 

PROVIDER: S-EPMC12003378 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature