Trazodone and Risk of Orthostatic Hypotension, Syncope and Falls in Geriatric Outpatients with Hypertension.

ABSTRACT:

Introduction

In older adults, trazodone is frequently prescribed for anxiety and insomnia owing to its perceived greater tolerability in comparison with benzodiazepines. However, it may have hypotensive effects.

Aim

The aim of this study is to investigate the effects of trazodone on orthostatic blood pressure (BP) response and risk of syncope and falls in hypertensive older adults.

Patients and methods

A longitudinal observational study involving patients ≥ 75 years was conducted in two geriatric outpatient clinics in Florence, Italy. At baseline, participants underwent a 3-min active stand test, office BP measurement and home and ambulatory BP monitoring. At follow-up, syncope and falls were recorded.

Results

Among 123 participants (mean age 81 years, 59% fema

SUBMITTER: Rivasi G 

PROVIDER: S-EPMC12003544 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature