Development of an SI traceable value assigned amino acid matrix-matched material to underpin European external quality assessment.

ABSTRACT: Plasma amino acid analysis plays a vital role in monitoring inherited metabolic diseases (IMDs), such as phenylketonuria (PKU), where dietary therapy is the cornerstone of management and patients are regularly monitored using blood or plasma phenylalanine throughout life. Recent findings from external quality assessment (EQA) schemes demonstrate large variability between results from different clinical laboratories. EQA schemes are hampered by factors including suboptimal sample type and frequency of distributions. Aiming to harmonise and standardise EQA schemes, this paper describes value assignment of an SI traceable matrix-matched amino acid material, and its use in an interlaboratory comparison (ERNDIM QAA-2106 study) that included 89 clinical laboratories from throughout Europe. The o

SUBMITTER: Whyte E 

PROVIDER: S-EPMC12003604 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature