Identification of new candidates regulating autophagy-dependent midgut degradation in Drosophila melanogaster.

ABSTRACT: Autophagy-dependent cell death (ADCD) is a context-specific form of programmed cell death that plays an important role in development and homeostasis. During Drosophila metamorphosis, hormonal cues modulate growth and other signalling cascades which results in autophagy-dependent degradation of the obsolete larval midgut. While this process does not require caspase activity or apoptotic machinery, several canonical autophagy-related proteins are also dispensable, suggesting additional regulators may be involved in effectively eliminating the larval midgut. Ubiquitination, a process that attaches one or more ubiquitin moieties to a substrate through sequential reactions involving a cascade of enzymes, plays a critical role in autophagy. As the specific role(s) of ubiquitination in ADCD has

SUBMITTER: Umargamwala R 

PROVIDER: S-EPMC12003636 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature