Associations between skeletal muscle strength and chronic kidney disease in patients with MASLD.

ABSTRACT:

Background

A skeletal muscle strength (SMS) decline is associated with metabolic diseases, but whether SMS also declines with chronic kidney disease (CKD) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) is uncertain. This study examined the associations between SMS and the risk of CKD in MASLD population.

Method

We performed a large-scale study with four cohorts: PERSONS and NHANES 2011-2014 cohorts for the cross-sectional investigation, and TCLSIH and UK Biobank cohorts for the longitudinal investigation. A handgrip dynamometer measured handgrip strength as a proxy for overall SMS. Participants were stratified according to CKD status [non-CKD vs. CKD (stages 1-5) groups].

Results

In the PERSONS cohort, the CKD group has a lower ha

SUBMITTER: Zhang XL 

PROVIDER: S-EPMC12003656 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature