Inflammatory conditions shape phenotypic and functional characteristics of lung-resident memory T cells in mice.

ABSTRACT: Lung tissue-resident memory T cells (T_RM) are critical for the local control of respiratory tract infections caused by influenza A viruses (IAV). Here we compare T_RM populations induced by intranasal adenoviral vector vaccines encoding hemagglutinin and nucleoprotein (NP) with those induced by an H1N1 infection in BALB/c mice. While vaccine-induced T_RM express high levels of CD103 and persist longer in the lung parenchyma, short-lived, H1N1-induced T_RM have a transcriptome associated with higher cytotoxic potential and distinct transcriptional profile as shown by single-cell RNA sequencing. In both the vaccine and H1N1 groups, NP-specific CD8⁺ T cells expand during heterologous influenza virus infection and protect the mice from diseas

SUBMITTER: Schmidt A 

PROVIDER: S-EPMC12003732 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature