Visible light-mediated dearomative spirocyclization/imination of nonactivated arenes through energy transfer catalysis.

ABSTRACT: Aromatic compounds serve as key feedstocks in the chemical industry, typically undergoing functionalization or full reduction. However, partial reduction via dearomative sequences remains underexplored despite its potential to rapidly generate complex three-dimensional scaffolds and the existing dearomative strategies often require metal-mediated multistep processes or suffer from limited applicability. Herein, a photocatalytic radical cascade approach enabling dearomative difunctionalization through selective spirocyclization/imination of nonactivated arenes is reported. The method employs bifunctional oxime esters and carbonates to introduce multiple functional groups in a single step, forming spirocyclic motifs and iminyl functionalities via N-O bond cleavage, hydrogen-atom transfer, ra

SUBMITTER: Zhou C 

PROVIDER: S-EPMC12003774 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature