Clinical implications of squamous cell carcinoma in the colon and rectum: A comprehensive analysis from the National Cancer Database.

ABSTRACT:

Aim

Squamous cell carcinoma (SCC) of the colon and rectum represents an exceptionally rare manifestation of gastrointestinal malignancy. The primary aim of this study was to elucidate baseline characteristics of colon SCC and its impact on overall survival (OS) in comparison with rectal SCC.

Method

We conducted a retrospective analysis utilizing the National Cancer Database encompassing patients diagnosed with SCC of the colon and rectum from 2004 to 2019. Propensity score matching was employed to facilitate the comparison of OS between patients diagnosed with rectal and colon SCC who underwent surgery across four different tumour stages, with each stage evaluated individually.

Results

A cohort comprising 249 colon SCC cases and 5398 rectal SCC cases was analysed. Col

SUBMITTER: Erkaya M 

PROVIDER: S-EPMC12003965 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature