Characterization of extracellular vesicle miRNA identified in peripheral blood of chronic pancreatitis patients.

ABSTRACT: Plasma-derived extracellular vesicles (EV) can serve as markers of cell damage/disease but can also have therapeutic utility depending on the nature of their cargo, such as miRNA. Currently, there are challenges and lack of innovations regarding early diagnosis and therapeutic options within different aspects of management of patients suffering from chronic pancreatitis (CP). Use of EV as biomarkers for pancreatic health and/or as adjuvant therapy would make a difference in management of these patients. The aim of this study was to characterize the miRNA cargo of EV purified from the plasma of CP patients and compared to those of healthy participants. EVs were isolated from plasma of 15 CP patients and 10 healthy controls. Nanoparticle tracking analysis was used to determine frequency and

SUBMITTER: Desai CS 

PROVIDER: S-EPMC12003975 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature