The impact of blood pressure targets on venous return physiology during post cardiac arrest care.

ABSTRACT:

Background

Venous return (VR) physiology may be elucidated using a calculated mean systemic filling pressure analogue (P_msa) that reflects the stressed intravascular volume. The aim of this study was to explore differences in VR physiological variables with the hypothesis that vasopressor therapy targeting a higher mean arterial pressure (MAP) would associate with an increased volume state. This would be important to appreciate the intravascular volume effect of an intervention that traditionally is judged by the pressure response alone.

Methods

This exploratory study used data from the BOX trial that investigated a higher (MAP of 77 mmHg, MAP77) versus a lower (63 mmHg, MAP63) blood pressure target during intensive care of survivors from out-of-hospital cardiac a

SUBMITTER: Schneekloth S 

PROVIDER: S-EPMC12004033 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature