Opto-sensing of sotalol using parafilm and poly(methyl methacrylate) micro-plates decorated by silver nanoparticles: state-of-the-art for one-drop pharmaceutical analysis.

ABSTRACT: Sotalol is an antiarrhythmic drug with a narrow therapeutic index and potential adverse effects, including hypotension and heart block, requiring continuous and precise blood-level monitoring. In this study, an innovative optical sensor was developed using silver nanoparticle (AgNP)-functionalized parafilm (PF)- and poly methyl methacrylate (PMMA) for the trace-level detection of sotalol in human blood plasma. The detection was performed using CMYK-based colorimetric digital image analysis via the Color Picker software app, achieving a low limit of quantification of 1 μM and a linear range of 0.001 to 20 mM. The selectivity of the sensor was also validated in the presence of potentially interfering cardiovascular drugs. Nanoparticle characterization revealed a shift in zeta potentia

SUBMITTER: Behyar MB 

PROVIDER: S-EPMC12004068 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature