Piperazine-Based Co(III), Ni(II), Cu(II), and Zn(II) Carbodithioate Complexes as Potential Anticancer Agent.

ABSTRACT: The development of facile and cost-effective anticancer metallodrugs possessing minimal side effects is urgently needed. Piperazine-containing anticancer drugs are already available on the market. A piperazine-based potassium 4-(ethoxycarbonyl)piperazine-1-carbodithioate [pecpcdt] (L) ligand and its metal complexes [Co(ecpcdt)₃] (1), [Ni(ecpcdt)₂] (2), [Cu(ecpcdt)₂] (3), and [Zn(ecpcdt)₂] (4) were synthesized. These compounds were characterized by different spectroscopic methods and single-crystal X-ray crystallography data. Ni(II) and Cu(II) complexes have distorted square planar geometry, whereas the Co(III) complex has distorted octahedral geometry around the metal ions. Complexes are weakly fluorescent in th

SUBMITTER: Gupta S 

PROVIDER: S-EPMC12004137 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature