Enantioselective Crystallization on Chiral Hybrid Magnetic Polymeric Particles.

ABSTRACT: A new class of Janus chiral magnetic polymeric particles was fabricated for chiral resolution by enantioselective crystallization. N-Acryloyl-l/d-Phe methyl ester beads were prepared with controlled sizes and coated with ferromagnetic permalloy. Chiral discrimination by enantiopure d-Ala crystals was investigated in a model for racemic crystallization. X-ray diffraction and differential scanning calorimetry support the crystallization of the particles. Analysis of optical rotation reveals a d-Ala enantiomeric excess of about 11%, effectively establishing the concept of chiral discrimination by enantioselective crystallization on these Janus chiral magnetic polymeric particles.

SUBMITTER: Moshe YB 

PROVIDER: S-EPMC12004177 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature