Polygenic Scores and Mood Disorder Onsets in the Context of Family History and Early Psychopathology.

ABSTRACT:

Importance

Bipolar disorder (BD) and major depressive disorder (MDD) aggregate within families, with risk often first manifesting as early psychopathology, including attention-deficit/hyperactivity disorder (ADHD) and anxiety disorders.

Objective

To determine whether polygenic scores (PGS) are associated with mood disorder onset independent of familial high risk for BD (FHR-BD) and early psychopathology.

Design, setting, and participants

This cohort study used data from 7 prospective cohorts enriched in FHR-BD from Australia, Canada, the Netherlands, Spain, and the US. Participants with FHR-BD, defined as having at least 1 first-degree relative with BD, were compared with participants without FHR for any mood disorder. Participants were repeatedly assessed with variab

SUBMITTER: Freeman K 

PROVIDER: S-EPMC12004201 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature