Sex, Neural Networks, and Behavioral Symptoms Among Adolescents With Multisite Pain.

ABSTRACT:

Importance

Multisite pain disproportionately affects females starting in adolescence and is associated with central nervous system dysregulation. Understanding the heterogeneity of underlying neural networks and behavioral symptoms is essential.

Objective

To characterize sex-related resting-state neural networks and co-occurring symptoms, including sleep and behavioral problems, in youth with multisite pain.

Design, setting, and participants

This cross-sectional analysis leverages the 2-year follow-up data from the Adolescent Brain and Cognitive Development Study. A total of 684 youth aged 11 to 12 years with multisite pain were compared with 1368 youth with no pain or with regional pain, matched by pubertal status, handedness, and race and ethnicity. Data were collec

SUBMITTER: Hidalgo-Lopez E 

PROVIDER: S-EPMC12004202 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature