Differential expression of novel potential regulators in hematopoietic stem cells.

ABSTRACT: The hematopoietic system is an invaluable model both for understanding basic developmental biology and for developing clinically relevant cell therapies. Using highly purified cells and rigorous microarray analysis we have compared the expression pattern of three of the most primitive hematopoietic subpopulations in adult mouse bone marrow: long-term hematopoietic stem cells (HSC), short-term HSC, and multipotent progenitors. All three populations are capable of differentiating into a spectrum of mature blood cells, but differ in their self-renewal and proliferative capacity. We identified numerous novel potential regulators of HSC self-renewal and proliferation that were differentially expressed between these closely related cell populations. Many of the differentially expressed transcrip

SUBMITTER: Forsberg EC 

PROVIDER: S-EPMC1200425 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature