Highly Extensible Physically Crosslinked Hydrogels for High-Speed 3D Bioprinting.

ABSTRACT: Hydrogels have emerged as promising materials for bioprinting and many other biomedical applications due to their high degree of biocompatibility and ability to support and/or modulate cell viability and function. Yet, many hydrogel bioinks have suffered from low efficiency due to limitations on accessible printing speeds, often limiting cell viability and/or the constructs which can be generated. In this study, a highly extensible bioink system created by modulating the rheology of physically crosslinked hydrogels comprising hydrophobically-modified cellulosics and either surfactants or cyclodextrins is reported. It is demonstrated that these hydrogels are highly shear-thinning with broadly tunable viscoelasticity and stress-relaxation through simple modulation of the composition. Rheolog

SUBMITTER: Song YE 

PROVIDER: S-EPMC12004426 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature