Novel Protein-Rich Bioactive Bioink Stimulates Cellular Proliferation and Response in 3D Bioprinted Volumetric Constructs.

ABSTRACT: 3D extrusion bioprinting, a promising and widely adopted technology in the emerging field of biofabrication, has gained considerable attention for its ability to fabricate hierarchically structured, native-mimicking tissue substitutes with precisely defined cell distributions. Despite notable advancements, the limited availability of suitably bioactive bioinks remains a major challenge, hindering the construction of volumetric tissue substitutes effectively mimicking biological functionality. Therefore, this work proposes a protein-rich, low-cost, bioactive bioink: abundantly available eggwhite powder (EWP) is leveraged to functionalize an alginate-methylcellulose (AlgMC) hydrogel matrix and enhance cellular response. The developed EWP-supplemented bioinks not only maintain favorable print

SUBMITTER: Liu S 

PROVIDER: S-EPMC12004440 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature